Rosie O’Donnell, the comedian and TV personality, recently celebrated her progress in a weight-loss journey on Instagram. At age 63, she shared a photo of herself looking slimmer and credited the medication Mounjaro as part of her transformation. O’Donnell expressed amazement at her new size, moving from XXL to a size large, highlighting how significant the change feels for her.
Mounjaro’s Diabetes Treatment Also Supports Weight Loss Through Lifestyle Changes Abroad
Mounjaro (tirzepatide) is an injectable prescription medication primarily prescribed to adults with type 2 diabetes to improve blood sugar levels. A weight-loss version of the drug, called Zepbound, helps reduce excess body weight in people dealing with obesity or related health issues. The medication has gained attention from several celebrities for its weight loss benefits.

O’Donnell revealed that her move to Ireland earlier this year with her child, Clay, sparked lifestyle changes that aided her weight loss. Unlike her life in Los Angeles, where she had a personal chef, she now cooks for herself and her child, contributing to healthier habits. She mentioned that Mounjaro’s weight-loss side effects also played a significant role in her progress.
Celebrities Praise Mounjaro’s Benefits, While Rosie Advocates For Affordable Access
Other well-known figures like Whoopi Goldberg and Eric Stonestreet have also publicly credited Mounjaro for their weight loss. However, O’Donnell addressed the high cost of the medication, which is over $1,000 per prescription. She expressed frustration about its affordability and advocated for free access for those who need it, especially people with diabetes or obesity-related conditions.
Beyond the physical changes, O’Donnell’s posts reflect a deeper emotional journey. She openly discussed her long-standing struggles with weight and body image, calling her transformation “life-altering.” Despite the challenges, her openness about using medication and lifestyle changes highlights hope and progress in managing health in later life.

